Several hypotheses are floating about as to what may be the root cause of autism. One of these variables is the leaky gut hypothesis, and another is the use of thimerosal in vaccinations. Nevertheless, there are still a lot of questions that have not been addressed.
Despite the significant study conducted, it is still unclear whether a leaky gut causes autism. On the other hand, researchers have shown that autistic children are more likely than ordinary children to suffer from a condition known as a leaky gut. According to one idea, bacterial overgrowth in the stomach is thought to be the root cause of a leaky gut. This may lead to undigested food particles entering the circulation, which triggers a reaction from the immune system and manifests as physical symptoms.
Autism may be caused by a combination of variables, one of which is a leaky gut syndrome. Researchers have shown that autistic children have higher amounts of metabolites in their systemic circulation and urine than typically developing youngsters do. These metabolites have the potential to have an immediate impact on neurodevelopment.
Other research has shown a connection between autism and food. Children diagnosed with autism showed a reduction in the quantity of Moraxella bacteria, according to the findings of one research. On the other hand, these outcomes were not always the same.
If you have Asperger's syndrome, it does not always indicate that you are "special." On the other hand, it may indicate that you have problems interacting with other people in social settings. It's possible that you need assistance establishing eye contact, comprehending jokes, or interpreting body language. You can have a monotonous voice or a tendency to repeat the same habits.
There is a school of thought amongst professionals that holds that environmental variables are contributors to Asperger's. Infections contracted by the mother, the mother's age, and the use of assisted reproductive technologies are some of these risks. There is a possibility that children's brains will grow differently as a result of these variables.
Genetics may also play a role in the development of autism. Autism may be caused by genetic diseases that only damage a single gene. However, these illnesses can still have a substantial effect. The connection between brain cells is influenced by genetics. This may eventually result in Asperger's syndrome. According to the findings of research conducted in 2008, more than ninety percent of individuals with Asperger's syndrome also had concurrent psychotic illnesses.
Thimerosal is a chemical that is used as a preservative and bacteriostatic agent, and it is present in vaccines. The amount of thimerosal that is included in vaccinations might vary greatly from one shot to the next. Thimerosal is now included in over 30 different vaccinations that are sold in the United States.
There have been several investigations on the possible link between autism and the presence of thimerosal in vaccines. However, they have not discovered any association between the two. Autism is becoming more prevalent in today's society. Some experts have a hunch that a greater awareness of the condition, as well as modifications to diagnostic criteria, may be to blame for the rise in the number of cases.
Several research were analyzed by the Immunization Safety Review Committee to determine whether or not there is a connection between immunizations and autism. It was discovered that immunizations were linked to an increased risk of autism; however, there were no consistent significant connections discovered. In addition, the committee concluded that the research did not present enough data to support the hypothesis that there is a causal relationship between thimerosal and autism.
There have been several studies that have pointed to the possibility that autistic persons have elevated amounts of opioid peptides in their urine. They also suggested that these peptides could play a role in the manifestation of autism.
Researchers devised a technique that included analyzing the urine of autistic youngsters to find endogenous opioids. According to the findings of their research, opioid peptides have been found in the urine of children with autism but not in the urine of typically developing youngsters.
It is believed that mutations in the DPPIV gene are responsible for the existence of endogenous opioids in the body. Inflammation is something that has to be controlled, and DPPIV is responsible for doing just that. An excess of exogenous opioids may cause the DPP4 enzymes to become saturated, which increases the body's natural production of endogenous opioids. On the other hand, the DPPIV activity in women is much lower than that in males. The decline in DPPIV activity has been linked to a compromised immunological state.
It has been shown that microRNA-128 has a regulatory role in neurogenesis throughout development. These tiny RNA molecules are responsible for regulating the proliferation of neural progenitor cells (NPCs) in the neocortex that is still growing.
It is possible that miR-128 potentially regulates differentiation in addition to its role in controlling the proliferation of NPCs. The maturation of neural precursor cells (NPCs) into neurons is stimulated by excessive production of this short RNA. The proliferation of NPCs is stifled when this RNA is inhibited, which results in a reduction in the number of neurons.
Recent research has shown that the expression of miR-128 is growing at an accelerated rate in the developing cortex of mice. However, further information is needed to clarify how this is impacting the development of the cortex. According to the findings of a few pieces of research, the abnormal miR-128 expression could be to blame for abnormal cortical development. Zhang, Kim, and his coworkers investigated the function of miR-128 in the developing brain of mice for this research.
To explore the function of miR-128 throughout development, an in situ hybridization using miR-128 LNA was carried out, which was then followed by an immunofluorescence investigation of the neural stem cell marker NESTIN on coronal slices of the brain of E14.5 mouse embryos. At E14.5, it was discovered that there was miR-128 present in the cortical layers. In addition, an immunofluorescence examination of the NPC marker NESTIN revealed that the level of expression of miR-128 was elevated in the cells that were located inside the VZ/SVZ.